Why have nonprofits historically been seen as workhorses rather than leaders in the search for social innovation? In this panel discussion, Dr. David Shern, CEO of Mental Health America, and Father Larry Snyder, President of Catholic Charities USA, discuss the potential of nonprofits as catalysts for innovation in health care reform. Shern contextualizes the United States’ shortcomings and explains the need for equitable access to healthcare resources, both for preventative and treatment services. Snyder emphasizes the importance of a less monolithic measure of poverty and a more contemporary design for our current “safety net” solutions. “Leadership 18” members Dr. Shern and Father Snyder were invited by the Center for Social Innovation’s Public Management Program and the Center for Leadership Development and Research at the Stanford Graduate School of Business.