Microsoft founder Bill Gates transformed the world through his role in personal computing; now, he is transforming philanthropy, contributing to the betterment of those who live in poverty worldwide. In this audio lecture, Gates challenges Stanford MBA students to take on the world’s difficult problems as a focus of their career or life mission. He tells a bit about his own story, overviews the problems that face us globally, and suggests paths people can take to contribute to solutions. Gates spoke at the 2010 Stanford University commencement ceremony.